NeuroStar TMS was not compared in head-to-head studies with antidepressant medications. It is difficult to compare NeuroStar vs. drugs, because they have been studied in different patient populations.
The patients for which NeuroStar has been FDA-cleared had failed multiple treatment attempts, one of which achieved an adequate dose and duration. Almost all antidepressant medications have been studied and approved for 1st-line treatment.
In the NeuroStar randomized controlled trial, almost 3x the number of NeuroStar-treated patients had a significant improvement in symptoms compared to placebo.